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| factors | mesophilic α-CA | thermophilic α-CA |
|---|---|---|
| total surface area | 12 420 Å2 | 11 620 Å2 |
| number of hydrogen bond | 487 | 526 |
| number of salt bridges | 4 (all confined in a local region) | 5 (dispersed in different places) |
| number of proline residues | 15 (13 in loop) | 11 (all in loop) |
| charged residues | 44 | 62 |
