Table 1. Cytotoxicity of the Compounds (Chemical Structures in Figure 1) in Ovarian Tumor Cell Lines Sensitive to MSA (A2780) and MSA-Resistant due to P-gp Overexpression (A2780AD) and in Cervical Tumor Cell Lines Sensitive to MSA (HeLa S3) and MSA-Resistant due to β_III-Tubulin Overexpression (HeLa-β_III).

compound	A2780 (nM)	A2780AD (nM)	R/S	HeLa-S3 (nM)	HeLa βIII (nM)	R/S	Crb (μM)
dimethyl sulfoxide (DMSO, vehicle)							3.3 ± 0.1a
paclitaxel	1.8 ± 0.4	1491 ± 284	828.2	0.8 ± 0.2	8.6 ± 1.4	10.8	0.5 ± 0.1a
dictyostatin	2.55 ± 1	3.9 ± 0.2	1.5	1.5 ± 0.3	4.4 ± 0.8	2.9	0.4 ± 0.1
2	1203 ± 52	1423 ± 39	1.2	1050 ± 145	1160 ± 115.2	1.1	3.3 ± 0.3
discodermolide	28 ± 3	37.9 ± 5.2	1.35	6 ± 0.8	13.2 ± 1.25	2.2	0.6 ± 0.1
4	3.6 ± 1.5	5.1 ± 0.85	1.4	3.5 ± 0.7	10.2 ± 1.5	3.0	1.2 ± 0.1
5	5.5 ± 1.2	4.7 ± 1.6	0.85	9.7 ± 1.9	35 ± 2	3.6	1.4 ± 0.1
6	33.3 ± 11.6	16 ± 0.7	0.5	13 ± 3	18.5 ± 1.1	1.4	2.2 ± 0.2
7	7000 ± 300	8575 ± 125	1.2	2627.5 ± 182	7275 ± 625	2.8	3.4 ± 0.2
8	30.6 ± 8.2	17.6 ± 0.45	0.6	16.7 ± 3.2	15.3 ± 1.4	0.9	2.4 ± 0.1
9	4.9 ± 0.8	6.9 ± 0.4	1.4	1.9 ± 0.1	6.15 ± 0.8	3.2	0.5 ± 0.1
10	42.95 ± 4.7	94.4 ± 2.7	2.2	18.3 ± 1.9	21 ± 1.5	1.2	1.4 ± 0.2
11	66.6 ± 8.9	260 ± 43	3.9	25.85 ± 1.3	31.35 ± 4	1.2	0.8 ± 0.1
12	1.9 ± 0.9	0.9 ± 0.1	0.5	0.5 ± 0.02	1.8 ± 0.2	3.6	1.1 ± 0.1
13	69 ± 1.7	413.5 ± 21.6	6	32.6 ± 4.65	31.2 ± 6.5	1.0	1.2 ± 0.1
14	101.5 ± 3.95	89.3 ± 3.9	0.9	34 ± 3	67 ± 5.4	1.9	1.5 ± 0.2
15	488 ± 35	551.5 ± 53.3	1.1	719 ± 39	1047.5 ± 120	1.5	0.9 ± 0.1
16	2933 ± 219	4733 ± 437	1.6	2360 ± 133	1450 ± 104.1	0.6	1.8 ± 0.1

^aData taken from ref (3).

^bCr for tubulin assembly in the GAB buffer.