Table 2. Results of Enzyme Immunoassays Showing the Role of Compounds 6, 10, 12, and 17 (Final Concn 1 μM) in Inhibition of Calcium Ionophore-Stimulated TXB2 and LPS-Stimulated PGE2 in Whole Blood.
TXB2 (ng/mL) |
PGE2 (ng/mL) |
|||
---|---|---|---|---|
–calcium ionophore | +calcium ionophore | –LPS | +LPS | |
control | 0.16 | 2.00 | 0.145 | 1.98 |
indomethacin | 1.05 | 1.35 | ||
6 | 1.85 | 0.91 | ||
10 | 1.55 | 1.02 | ||
12 | 1.75 | 0.95 | ||
17 | 1.70 | 1.00 |