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. Author manuscript; available in PMC: 2018 Jul 13.
Published in final edited form as: Nat Protoc. 2018 Mar 29;13(5):819–839. doi: 10.1038/nprot.2017.148

Figure 2: Quantile normalization and Loess smoothing allow comparison between samples.

Figure 2:

A.: Replication timing (RT) profiles of two technical repli-seq replicates (F121–9 mouse ESC, mapped on mm10) before and after each normalization step. Data are visualized using IGV. B.: Correlation between log ratio early / late at indicated step of normalization of 50kb windows along the genome of samples in A. R = Pearson correlation coefficient,