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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Pancreas. 2018 Aug;47(7):856–863. doi: 10.1097/MPA.0000000000001090

FIGURE 1.

FIGURE 1

Anti-NGF treatment alters levels of mRNAs encoding genes related to nociception and neurogenic inflammation in DRG T9–T12. A, TrkA and (B) p75 mRNA levels are significantly reduced following anti-NGF treatment regardless of age at onset of intervention. C, Substance P (Tac1) mRNA is significantly decreased in ganglia from mice treated with anti-NGF beginning at 8 wk of age. D, CGRP (CalcB) is significantly down regulated by anti-NGF. E) TRPV1 mRNA levels are unchanged by anti-NGF treatment. F, TRPA1 mRNA is significantly increased in thoracic DRG in the 4 wk anti-NGF group. Fold change data were compared by two-way ANOVA followed by Sidak post-hoc test. *P < 0.05, ***P < 0.001, ****P < 0.0001 n = 6–10/group.