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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Pancreas. 2018 Aug;47(7):856–863. doi: 10.1097/MPA.0000000000001090

FIGURE 4.

FIGURE 4

Anti-NGF inhibits perineural migration of pancreatic lineage cells into the thoracic spinal cord. Representative micrographs of the ventral thoracic spinal cord of KPC mice treated with anti-NGF starting at 4 wk (A) or at 8wk of age (B). Pancreas-lineage cells are identified by tdTomato expression (red); neurons are immunolabeled with anti-NeuN (green). C, The proportion of mice exhibiting perineural invasion is reduced in the 8 wk anti-NGF group (logistic regression analysis, P t6 = 0.045). D, The number of tdTomato positive cells (sum of 5 tissue sections per mouse) is reduced in mice that received anti-NGF treatment beginning at 8 wk (two-way ANOVA followed by Sidak’s post-hoc test). Cells within a 0.25mm2 region of interest (indicated in panel B) were counted. *P < 0.05, ***P < 0.001, n = 5–8/group. Scale bar = 100µm. Mn = motor neuron