Table 1. Biodistribution of ^99mTc-HYNIC-ZD2 in Mice Bearing MDA-MB-468 Tumors^a.

	1 h		2 h		3 h
organs	%ID/g	T/B ratio	%ID/g	T/B ratio	%ID/g	T/B ratio
brain	0.0076 ± 0.0005	56.2	0.0045 ± 0.0045	42.0	0.0030 ± 0.0002	15.4
bone	0.0216 ± 0.0051	19.6	0.0211 ± 0.0211	9.1	0.0069 ± 0.0016	6.7
muscle	0.0616 ± 0.0148	6.9	0.0154 ± 0.0154	12.4	0.0109 ± 0.0026	4.2
intestine	0.0567 ± 0.0016	7.5	0.0331 ± 0.0331	5.8	0.0174 ± 0.0005	2.6
liver	0.0617 ± 0.0018	6.9	0.0317 ± 0.0317	6.0	0.0239 ± 0.0007	1.9
spleen	0.0815 ± 0.0221	5.2	0.0609 ± 0.0609	3.1	0.0344 ± 0.0093	1.3
skin	0.0821 ± 0.0055	5.2	0.0382 ± 0.0382	5.0	0.0200 ± 0.0013	2.3
heart	0.0894 ± 0.0179	4.8	0.0511 ± 0.0511	3.7	0.0254 ± 0.0051	1.8
lung	0.2706 ± 0.0335	1.6	0.0989 ± 0.0989	1.9	0.0790 ± 0.0098	0.6
kidney	4.6816 ± 0.4054	0.1	0.5984 ± 0.5984	0.3	0.3813 ± 0.0330	0.1
tumor	0.4249 ± 0.0305	1.0	0.1907 ± 0.1907	1.0	0.0458 ± 0.0033	1.0

^aQuantification of the organ imaging confirmed that ^99mTc-HYNIC-ZD2 accumulated in the tumors and kidneys for excretion 1, 2, and 3 h after intravenous injection. The biodistribution data and T/B ratios were reported as an average plus the standard deviation at each time point.