Table 8. Determination of Telomerase Enzyme Inhibition Activity through TRAP-LIG Assay and Cytotoxicity of Ligands in Two Cancer Cell Lines (A549 and HeLa) and One Near-Normal (HEK 293T) Cell Line.
| A549 |
HeLa |
HEK 293T |
|||||
|---|---|---|---|---|---|---|---|
| ligands | TRAP assay IC50 | IC50 at 48 h | IC50 at 72 h | IC50 at 48 h | IC50 at 72 h | IC50 at 48 h | IC50 at 72 h |
| ALI-C3 | >50 | 1.8 | 1.4 | 2.4 | 2.1 | 12.2 | 8.9 |
| BBZ-ARO | 4.56 | 26.4 | 19.7 | 24.7 | 20.5 | 77.9 | 63.4 |
| BBZ-AROCH2 | >50 | 79.5 | 74.8 | 92.7 | 86.5 | >100 | >100 |
| BMSG-SH-3 | 25.4 | 17.2 | 6.2 | 20.9 | 11.4 | <0.78 | <0.78 |