Table 2. HDAC Inhibition Assays (IC50) Using Class I and Class IIa HDAC Isoforms.
| IC50 (μM) | ||||
|---|---|---|---|---|
| molecule | HDAC1 | HDAC3/NCOR2 | HDAC4 | HDAC8 |
| 3 | 0.96 ± 0.6 | 0.33 ± 0.01 | >100 | 7.02 ± 1.53 |
| 13 | 0.39 ± 0.02 | 0.35 ± 0.003 | >100 | 1.87 ± 0.42 |
| 11b | 7.9 ± 0.8 | 50.2 ± 4.7 | >100 | >100 |
| 11e | 5.04 ± 0.07 | 1.97 ± 0.03 | >100 | >100 |
| SAHAa | 0.123 ± 0.003 | 0.957 ± 0.07 | 0.101b | 1.52b |
| trichostatin A (TSA)a | 0.624 | |||
| TMP269a | 0.275 | |||
Assay-positive controls according to relevant isoform.
Data from ref (28).