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. 2017 Oct 19;2(10):6939–6957. doi: 10.1021/acsomega.7b00741

Figure 5.

Figure 5

Safety profiles of the peptide libraries and the peptide/siRNA complexes in human cell lines. The viability of MDA-MB-231 (A) and MDA-MB-435 (B) cell lines after 72 h of exposure to different peptide concentrations (left panels) and peptide/siRNA complexes in a range of peptide/siRNA ratios (right panels) are presented for linear (upper panels) and cyclic (lower panels) peptide libraries. Linear peptide conjugated with C12 fatty acid showed the most significant toxicity in both cell lines. Data are presented as mean, n = 3, and the error bars represent standard deviation. The asterisks represent a significant difference (p < 0.05) compared to “no treatment” cells (representing 100% viability; data for which is not included in the figure).