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. 2017 Oct 19;2(10):6939–6957. doi: 10.1021/acsomega.7b00741

Figure 6.

Figure 6

Cellular uptake of FAM-siRNA by human cancer cell lines. The internalization of FAM-labeled siRNA into MDA-MB-231 (the upper panels in each set) and MDA-MB-435 (the lower panels in each set) cells for linear (left panels in each set) and cyclic (right panels in each set) peptides is presented as percentage of the cells positive for siRNA uptake (A) and average of the fluorescence in the cell population (B). The cells were transfected by two different peptide/siRNA w/w ratios (20:1 and 40:1 for linear and 80:1 and 120:1 for cyclic peptides). Linear peptide conjugated with C16 and C18 fatty acids demonstrated the most efficient intracellular siRNA delivery. Data are presented as mean, n = 3, and the error bars represent standard deviation.