. 2017 Jun 1;2(6):2422–2431. doi: 10.1021/acsomega.7b00310

Table 3. EC₅₀ Values for Quinazoline–Artemisinin Hybrids 9/10 and Its Precursor 14 in Sensitive Wild-Type CCRF-CEM and Multidrug-Resistant P-Glycoprotein-Overexpressing CEM/ADR5000 Cells.

compound	molecular weight (g/mol)	CCRF-CEM EC₅₀ (μM)	CEM/ADR5000 EC₅₀ (μM)	degree of cross-resistance
doxorubicin^a	579.98	0.009	23.27	2585
artemisinin (5)^b	282.14	36.90 ± 6.90	26.90 ± 4.40	0.73
artesunic acid (16)	384.42	0.4 ± 0.1	0.1 ± 0.1	0.3
9	671.57	2.8 ± 0.2	0.6 ± 0.2	0.2

EC₅₀ values for both cell lines have been previously reported.⁶¹

EC₅₀ values for both cell lines have been previously reported.⁴²

Table 3. EC50 Values for Quinazoline–Artemisinin Hybrids 9/10 and Its Precursor 14 in Sensitive Wild-Type CCRF-CEM and Multidrug-Resistant P-Glycoprotein-Overexpressing CEM/ADR5000 Cells.