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. 2017 Oct 16;2(10):6741–6754. doi: 10.1021/acsomega.7b01085

Scheme 3. Synthesis of Dibenzodiazepinone-Type Homo- or Heterodimeric Ligands 58–61, 63, 64, 66, 67, 69, 70, and 72.

Scheme 3

Reagents and conditions: (a) (1) 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium, HOBt, DIPEA, DMF, 60 °C, 3 h; (2) TFA/CH2Cl2/H2O 10:10:1 v/v/v, rt, 2 h, 8% (58), 16% (60), 10% (63), 28% (66), 15% (69), 4% (72); (b) DIPEA, DMF, rt, 2 h, 79% (59), 89% (61), 88% (64), 83% (67), 86% (70).