Skip to main content
. 2017 Sep 18;2(9):5873–5890. doi: 10.1021/acsomega.7b00892

Table 5. PK Parameters for Selected Analogues in the Rata.

graphic file with name ao-2017-00892q_0008.jpg

compound MW C log P(d) Nvs (Psa) Vd,ss (L/kg) Cl (mL/(min kg)) PO AUC (ng h/mL) bioavailability (%F)
2 265.25 2.42 113.5 0.698 ± 0.327 57.5 ± 3.3 167 ± 10 5.8 ± 0.1
4 249.25 1.8 93.27 0.18 ± 0.006 6.1 ± 0.5 17 500 ± 2820 63.5 ± 6.9
13 279.28 2.87 113.5 0.160 ± 0.012 8.96 ± 0.51 13 600 ± 3890 72.5 ± 18.4
28 255.3 2.34 93.27 0.68 ± 0.12 69.8 ± 4.3 418 ± 96 17.5 ± 4.2
a

Clearance (Cl), volume of distribution (Vd,ss), area-under-the-curve (PO AUC), and bioavailability (%F) are the mean ± standard deviation of three animals. Studies were conducted in accordance with ethical guidelines.