Table 1. Possible Protein Targets and Available Drugs for Blocking ZIKV Infection Spread.
protein targets | drugs | references | |
---|---|---|---|
ZIKV | NS5 poymerase | 7DMA, 2′-C-methylcytidin, ribavirin, favipiravir, T-1105 | (13) |
virus replication | niclosamide | (4) | |
host factor | Axl receptor | warfarin, R428 | (21,22) |
BMS-777607, PF-02341066, Janssen | (65) | ||
RU-301, RU-302 | (23) | ||
our new hypothesis: compounds 1–5, compounds 1′ and 2′ | |||
caspase-3 | emricasan | (4) | |
host factors regarding virus packaging, virus secretion, immune surveillance | secretory system, immune proteins | (66−71) |