Table 3. Comparison of the Calculated Dissociation Constant and Experimentally Obtained Inhibitory Concentrations^a.

compound	Kd (calc.)b	IC (exp.)c
RU-301	12 μM	10 μM [22]
warfarin	139 μM
R428	18 nM	14 nM (IC50) [29]
compound 2′	0.24 nM

^aThe dissociation constants K_d for RU-301, warfarin, R428 and the designed compound 2′ have been calculated from ΔG values.⁷²

^bK_d (calc.)—calculated dissociation constant.

^cIC and IC₅₀—inhibitory concentration and half maximal inhibitory concentration, respectively, taken from experimental data.