Table 5. In Vitro Assays Used in the Potential Toxicity Prediction Based on the Trained Bayesian Models.
assay | description | |
---|---|---|
beta lactamase-based | HSE-blax | heat shock factor response element |
ARE-bla | antioxidant response element | |
P53-bla | P53 response element | |
VDR-bla | vitamin D receptor | |
PPAR-gamma-bla | peroxisome proliferator-activated receptor gamma | |
PPAR-delta-bla | peroxisome proliferator-activated receptor delta | |
AR-bla | androgen receptor | |
ER-bla | estrogen receptor | |
FXR-bla | farnesoid X receptor | |
GR-bla | glucocorticoid receptor | |
luciferase-based | TR-beta-luc | thyroid receptor beta |
AhR-luc | aryl hydrocarbon receptor | |
AR-MDA-luc | androgen receptor-responsive MDA breast cancer cell line | |
ER-BG1-luc | estrogen receptor-responsive ovarian adenocarcinoma BG1 cell line | |
various | DT40 WT | wild-type chicken DT40 bursal lymphoma cells |
DT40 REV3 | DT40 cells with DNA polymerase (REV3) mutation | |
ATAD5 | ATPase family AAA domain-containing protein 5 |