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Effect of preparation method and flow rate on PAX loading and in vitro release. (A) Loading efficiencies and (B) release profiles with corresponding plot of t1/2 vs fMCL (inset) for PAX-loaded PNPs of PMCL-50 (r = 0.25) prepared using the bulk preparation method and in the two-phase microfluidic reactor at different flow rates; in the inset to (B), Q = 0 μL/min designates the bulk-prepared PNPs.
