Table 5. Growth Inhibition (GI50 μM) Values of Analogues 1, 8e, 10a, 10b, 10e, 13i, 18, and 22 against a Panel of Human and Murine Cancer Cell Lines.
| compound |
||||||||
|---|---|---|---|---|---|---|---|---|
| cell line | 1 | 8e | 10a | 10b | 10e | 13i | 18 | 22 |
| HT29 | >50 | >50 | >50 | >50 | >50 | 15 ± 0.000 | >50 | 2.1 ± 0.050 |
| U87 | >50 | >50 | >50 | >50 | >50 | 29 ± 1.4 | >50 | 2.0 ± 0.10 |
| MCF-7 | >50 | >50 | >50 | >50 | >50 | 17 ± 0.82 | >50 | 2.3 ± 0.10 |
| A2780 | >50 | >50 | >50 | >50 | >50 | 18 ± 0.91 | >50 | 2.4 ± 0.14 |
| H460 | >50 | >50 | >50 | >50 | >50 | 21 ± 2.1 | >50 | 2.2 ± 0.065 |
| A431 | >50 | >50 | >50 | >50 | >50 | 17 ± 0.750 | >50 | 2.2 ± 0.11 |
| Du145 | >50 | >50 | >50 | >50 | >50 | 13 ± 0.41 | >50 | 1.7 ± 0.12 |
| BE2-C | >50 | >50 | >50 | >50 | >50 | 18 ± 3.2 | >50 | 2.3 ± 0.13 |
| SJ-G2 | >50 | >50 | >50 | >50 | >50 | 24 ± 2.6 | >50 | 1.8 ± 0.048 |
| MIA | >50 | >50 | >50 | >50 | >50 | 28 ± 0.82 | >50 | 2.4 ± 0.14 |
| SMA | >50 | >50 | >50 | >50 | >50 | 28 ± 4.4 | >50 | 2.9 ± 0.000 |
| MCF10A | >50 | >50 | >50 | >50 | >50 | 19 ± 0.50 | >50 | 2.8 ± 0.15 |