Table 3. In Vitro Synergistic Effect of 5e.
MIC
alone (μg/mL) |
MIC
in combination (μg/mL) |
|||||
---|---|---|---|---|---|---|
E. coli strain | 5e | CIP | 5e | CIP | FICIa | mode of interaction |
MRA11 | 1024 | 128 | 16 | 2 | 0.03 | synergistic |
MRC17 | 1024 | 128 | 16 | 2 | 0.03 | synergistic |
MRAE33 | 1024 | 2 | 16 | 2 | 1.02 | indifferent |
Synergy and antagonism were defined by FICI ≤ 0.5 and >4, respectively. Partially synergistic was denoted by 0.5 > FICI < 1, and indifferent was defined by 1 < FICI ≤ 4.