Scheme 1. Schematic Description of the Screening Procedure To Select Solid Forms Based on Solubility in Aqueous Media, in Fasted-State Simulated Gastric Fluid (FaSSGF) and in Fasted-State Simulated Intestinal Fluid (FaSSIF).

Step 1: screening CFZ for salt formation in various 1 M acidic solutions, isolation and monitoring of the solid phase present via vacuum filtration and PXRD. Step 2: determination of the supersaturation profile of the new solid form in deionized water, FaSSGF, and FaSSIF, followed by isolation and monitoring of the solid phase present via vacuum filtration and PXRD.