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. 2017 Dec 14;2(12):8969–8981. doi: 10.1021/acsomega.7b01454

Table 1. List of Coformers Used in Solid Form Screening, Their pKa Values, and ΔpKa Relative to CFZa.

coformers pKa ΔpKaa abbreviation
hydrochloric acid <−6 14.511 HCl
sulfuric acid –3 11.511 Sul
nitric acid –1.3 10.211 Nit
oxalic acid 1.27 7.241 Oxa
phosphoric acid 2.12 6.391 Pho
citric acid 3.1 5.411 Cit
formic acid 3.75 4.761 For
acetic acid 4.76 3.751 Ace
a

pKa CFZ taken as 8.511, as determined at 37 °C.29