Table 2. Comparison of the Maximum Supersaturation (Smax), Time to Reach Smax (tSmax), Initial Dissolution Rate (Dinitial) over the First 30 s, and Melting Points (mp) of CFZ Solid Forms in Deionised Water, FaSSGF and FaSSIF Media.
solid form | SH2Omax (mg/L) | tSmaxH2O (min) | DH2OInital (mg/L/min) | SFaSSGFmax (mg/L) | tSmaxFaSSGF (min) | DFaSSGFInitial (mg/L/min) | SFaSSIFmax (mg/L) | tSmaxFaSSIF (min) | DFaSSIFInitial (mg/L/min) | mp (°C) |
---|---|---|---|---|---|---|---|---|---|---|
CFZ F I | <0.01 | n/a | n/a | 6.942 ± 2.041 | 5 | 5.9516 | 2.236 ± 0.292 | 60 | 2.162 | 220.33 ± 0.58 |
CFZ-HCl | 7.406 ± 0.683 | 60 | 0.301 | 261.67 ± 1.53 | ||||||
CFZ-Sul | 82.052 ± 5.521 | 20 | 31.947 | 22.938 ± 2.436 | 1.5 | 27.371 | 8.916 ± 1.143 | 10 | 2.492 | 244 ± 0.82 |
CFZ-Nit | 6.718 ± 0.230 | 60 | 0.316 | 232.33 ± 0.58 | ||||||
CFZ-Oxa | 12.408 ± 0.035 | 60 | 1.189 | 194 ± 0.74 | ||||||
CFZ-Pho | 104.02 ± 9.108 | 7.5 | 75.605 | 24.472 ± 4.259 | 1.5 | 47.305 | 6.056 ± 1.540 | 20 | 3.383 | 215.25 ± 0.96 |
CFZ-Cit | 39.938 ± 7.515 | 20 | 12.389 | 21.689 ± 0.333 | 10 | 20.583 | 9.934 ± 0.630 | 10 | 6.155 | 203.50 ± 0.58 |
CFZ-For | 55.649 ± 5.399 | 20 | 19.505 | 8.062 ± 1.738 | 3 | 6.823 | 183.33 ± 0.58 | |||
CFZ-Ace | 67.215 ± 10.359 | 5 | 54.089 | 16.997 ± 1.339 | 15 | 6.5457 | n/a | |||
Lamprene | 16.925 ± 2.342 | 1.5 | 28.933 | 3.812 ± 0.187 | 60 | 3.614 | n/a |