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. 2017 Dec 14;2(12):8969–8981. doi: 10.1021/acsomega.7b01454

Table 2. Comparison of the Maximum Supersaturation (Smax), Time to Reach Smax (tSmax), Initial Dissolution Rate (Dinitial) over the First 30 s, and Melting Points (mp) of CFZ Solid Forms in Deionised Water, FaSSGF and FaSSIF Media.

solid form SH2Omax (mg/L) tSmaxH2O (min) DH2OInital (mg/L/min) SFaSSGFmax (mg/L) tSmaxFaSSGF (min) DFaSSGFInitial (mg/L/min) SFaSSIFmax (mg/L) tSmaxFaSSIF (min) DFaSSIFInitial (mg/L/min) mp (°C)
CFZ F I <0.01 n/a n/a 6.942 ± 2.041 5 5.9516 2.236 ± 0.292 60 2.162 220.33 ± 0.58
CFZ-HCl 7.406 ± 0.683 60 0.301             261.67 ± 1.53
CFZ-Sul 82.052 ± 5.521 20 31.947 22.938 ± 2.436 1.5 27.371 8.916 ± 1.143 10 2.492 244 ± 0.82
CFZ-Nit 6.718 ± 0.230 60 0.316             232.33 ± 0.58
CFZ-Oxa 12.408 ± 0.035 60 1.189             194 ± 0.74
CFZ-Pho 104.02 ± 9.108 7.5 75.605 24.472 ± 4.259 1.5 47.305 6.056 ± 1.540 20 3.383 215.25 ± 0.96
CFZ-Cit 39.938 ± 7.515 20 12.389 21.689 ± 0.333 10 20.583 9.934 ± 0.630 10 6.155 203.50 ± 0.58
CFZ-For 55.649 ± 5.399 20 19.505 8.062 ± 1.738 3 6.823       183.33 ± 0.58
CFZ-Ace 67.215 ± 10.359 5 54.089 16.997 ± 1.339 15 6.5457       n/a
Lamprene       16.925 ± 2.342 1.5 28.933 3.812 ± 0.187 60 3.614 n/a