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. 2018 Jan 29;3(1):1178–1186. doi: 10.1021/acsomega.7b01597

Figure 2.

Figure 2

(A) Alignment of C. glutamicum homoserine kinase (CglThrB) sequence with those of E. coli, M. jannaschii, and M. tuberculosis using CLUSTAL O (1.2.4). Conserved residues are shown with asterisk (*), residues with strongly similar properties are shown with a colon (:), and residues with weakly similar properties are shown with a period (.). The conserved Ala residues in motif I are highlighted in yellow. The arrows represent β-strands, whereas the ovals represent α-helices. (B) Structure of C. glutamicum ThrB (CglThrB-WT) with modeled l-homoserine and AMP-PNP based on the structure of M. jannaschii ThrB, with these compounds bound in the active site.