Table 1. In Vitro Antimalarial Activity, Cytotoxicity, and SIs of 3-APA Analogs.

	IC50 (μM) ± SDa
compound	P. falciparum (W2)	Wi-26VA4	SIb
4a	53.7 ± 0.7	>300	>5.6
4b	37.7 ± 0.2	37.8 ± 5.0	1.0
4c	14.0 ± 0.6	6.4 ± 0.7	0.4
4d	8.9 ± 0.4	11.3 ± 1.4	1.2
5a	210.6 ± 12.7	>400	1.9
5b	>188	167.7 ± 10.5	ND
5c	14.7 ± 0.2	99.1 ± 11.2	6.7
5d	15.1 ± 0.8	34.1 ± 6.5	2.2
6a	180.2 ± 8.3	NDc	ND
6b	52.4 ± 8.9	ND	ND
6c	20.3 ± 0.2	ND	ND
6d	30.6 ± 2.7	ND	ND
CQd	0.4 ± 0.066	>100	>250

^aSD: standard deviation.

^bSI: selectivity index.

^cND: not determined.

^dCQ: chloroquine.