Table 1. pKa and ΔpKa Values of AMX and Coformers Used in This Study.
SI. no. | name | pKa | ΔpKa | ratio of AMX and acid |
---|---|---|---|---|
1 | amoxapine | 8.83 | ||
2 | d-(−)-tartaric acid | 2.72 | 6.11 | 1:1 |
3 | fumaric acid | 3.03 | 5.80 | 1:1 |
4 | d-(+)-tartaric acid | 2.72 | 6.11 | 1:1 |
5 | maleic acid | 3.05 | 5.78 | 1:1 |
6 | succinic acid | 3.55 | 5.28 | 1:1 |
7 | citric acid | 3.05 | 5.78 | 1:1 |
8 | malonic acid | 2.85 | 5.98 | 1:1 |
9 | l-malic acid | 3.20 | 5.63 | 1:1 |
10 | adipic acid | 4.43, 5.41 | 4.4, 3.42 | 1:1 |