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AFM images of insulin aggregates prepared at 60 °C. The pH of the solution was 1.8. (A) Insulin oligomers having 3–5 nm diameter obtained after 60 min of incubation. (B) Pre-protofibrils obtained after 120 min of incubation. (C) Three-dimensional views of pre-protofibrils. (D) Protofibrils of diameter 5–8 nm obtained after 135 min. (E) Thin and thick fibrils of insulin, as obtained after 160 min. (F) Mature fibrils after 180 min of incubation.
