Table 1.
Demographics, comorbidities and clinical characteristics of patients at baseline in each temperature group
| Demographic variables | No change (n=11) |
Increasing (n = 9) |
Decreasing (n=9) |
Fluctuating (n=56) |
P Value |
|---|---|---|---|---|---|
| Age in Years, median [IQR] | 54 [31] | 59 [23] | 61 [21] | 60 [18] | 0.38 |
| Sex, n (%) | 0.40 | ||||
| Female | 3 (27) | 4 (44) | 6 (67) | 27 (48) | |
| Race, n (%) | 0.08 | ||||
| Caucasian | 4 (40) | 4 (44) | 7 (78) | 18 (32) | |
| African American | 3 (30) | 4 (44) | 2 (22) | 32 (59) | |
| Other | 3 (30) | 1 (11) | 0 (0) | 5 (8) | |
| Diagnosis on Admission, n (%) | 0.89 | ||||
| ICH | 3 (27) | 4 (44) | 4 (44) | 15 (27) | |
| ICH Score, median [IQR] | 3.5 [1] | 2 [1] | 3 [1] | 3 [2] | 0.92 |
| Aneurysmal SAH | 2 (18) | 2 (22) | 1 (11) | 12 (21) | |
| Grade (modified Fischer scale), median [IQR] | 2 [2] | 4 [2] | 4 [0] | 4 [0] | 0.16 |
| TBI | 3 (27) | 3 (33) | 1 (11) | 9 (16) | |
| Marshall Score, median [IQR] | 6 [0] | 5 [2] | 3 [0] | 3 [1] | 0.02 |
| Status Epilepticus | 1 (9) | 0 (0) | 1 (11) | 7 (13) | |
| Ischaemic Stroke | 1 (9) | 0 (0) | 2 (22) | 8 (14) | |
| NIHSS, median [IQR] | 25 [0] | – | 25.5 [7] | 20.5 [5] | 0.44 |
| Other (Meningitis, Encephalopathy, Post-Cardiac Arrest) | 1 (9) | 0 (0) | 0 (0) | 5 (9) | |
| GCS at Coma Onset, median [IQR] | 3 [3] | 7 [2] | 7 [2] | 7 [4] | 0.14 |
| Midline Shift at Pineal in mm*, median [IQR] | 0.5 [5.6] | 2 [6] | 0 [3] | 0 [3] | 0.06 |
| Brain HerniationT, n (%) | 4 (36) | 2 (22) | 3 (33) | 15 (27) | 0.85 |
| HbŦ, median [IQR] | 11 [4.2] | 9.9 [1.3] | 11.4 [2.3] | 10 [2] | 0.63 |
| PaCO2Ŧ, median [IQR] | 37.5 [13] | 34.5 [6.2] | 37.5 [9.8] | 37.5 [8] | 0.63 |
| Infection presentT, n (%) | 1 (9) | 2 (22) | 3 (33) | 10 (18) | 0.57 |
| Mean COxŦ, median [IQR] | 0.08 [0.14] | 0.02 [0.11] | 0.09 [0.14] | 0.05 [0.10] | 0.79 |
| Mean rSO2Ŧ, median [IQR] | 66 [12] | 57 [16] | 63 [8] | 60 [20] | 0.13 |
| ICP Max, median [IQR] | 16.7 [8] | 18.3 [18.5] | 31 [23] | 17 [21] | 0.54 |
| Use of cooling or warming device | 3 (27) | 2 (22) | 3 (33) | 20 (36) | 0.89 |
| PressorsT | 5 (45) | 4 (44) | 7 (78) | 26 (46) | 0.38 |
| SedationT | |||||
| Propofol | 1 (9) | 3 (33) | 0 (0) | 11 (20) | 0.27 |
| Fentanyl | 3 (27) | 5 (56) | 5 (56) | 23 (41) | 0.51 |
| Midazolam | 0 (0) | 0 (0) | 0 (0) | 3 (5) | 1.00 |
| Dexmedetomidine | 3 (27) | 0 (0) | 1 (11) | 7 (13) | 0.38 |
No change group: <1°C difference between highest and lowest temperature during monitoring period; Increasing temperature group: ≥1°C increase in temperature throughout monitoring period; Decreasing temperature group: ≥1°C decrease in temperature throughout monitoring period; Fluctuating temperature group: ≥1°C difference between highest and lowest temperature during monitoring period but no consistent direction of change.
Abbreviations: IQR: interquartile range; ICH: Intracranial Haemorrhage; SAH: Subarachnoid Haemorrhage; TBI: Traumatic Brain Injury; NIHSS: National Institutes of Health Stroke Scale
maximum recorded throughout monitoring period, T at any time during the monitoring period, Ŧ mean recording from entire duration of monitoring period