Table 1.
Risk of Hospitalized Allopurinol-Associated Severe Cutaneous Adverse Reactions (AASCARs) according to Race/Ethnicity and Other Risk Factors
| Variable | Allopurinol Initiators N (%) |
Hospitalized AASCARs N |
Risk of Hospitalized AASCARs (/1000 persons) | Age-, Sex-Adjusted Relative Risk | Multivariable-Adjusted Relative Risk* |
|---|---|---|---|---|---|
| All | 400,401 (100) | 203 | 0.51 (0.45 to 0.59) | – | – |
| Race/Ethnicity | |||||
| White/Hispanic | 248,501 (62) | 64 | 0.26 (0.20 to 0.33) | 1.0 | 1.0 |
| Black | 111,619 (28) | 91 | 0.82 (0.66 to 1.00) | 3.02 (2.20 to 4.17) | 3.00 (2.18 to 4.14) |
| Asian | 21,442 (5) | 15 | 0.70 (0.39 to 1.15) | 2.94 (1.67 to 5.17) | 3.03 (1.72 to 5.34) |
| Native Hawaiian/Pacific Islander | 18,839 (5) | 33 | 1.75 (1.21 to 2.46) | 6.54 (4.28 to 10.00) | 6.68 (4.37 to 10.22) |
| Sex | |||||
| Male | 213,041 (53) | 61 | 0.29 (0.22 to 0.37) | 1.0 | 1.0 |
| Female | 187,360 (47) | 142 | 0.76 (0.64 to 0.89) | 2.37 (1.74 to 3.21) | 2.49 (1.83 to 3.38) |
| Age | |||||
| <60 years | 208,151 (52) | 70 | 0.34 (0.26 to 0.42) | 1.0 | 1.0 |
| ≥60 years | 192,250 (48) | 133 | 0.71 (0.60 to 0.84) | 1.73 (1.29 to 2.33) | 1.66 (1.23 to 2.24) |
| Chronic Kidney Disease | |||||
| No | 381,561 (95) | 184 | 0.48 (0.42 to 0.56) | 1.0 | 1.0 |
| Yes | 18,840 (5) | 19 | 1.01 (0.63 to 1.54) | 2.11 (1.32 to 3.39) | 2.33 (1.44 to 3.77) |
| Initial Allopurinol Dose (>100 mg/d) | |||||
| No | 157,138 (39) | 58 | 0.37 (0.28 to 0.47) | 1.0 | 1.0 |
| Yes | 243,263 (61) | 145 | 0.60 (0.51 to 0.70) | 1.74 (1.28 to 2.36) | 1.85 (1.36 to 2.51) |
*
Mutually adjusted for the variables in this table.