Table 4.

Mortality of Allopurinol-Associated Severe Cutaneous Adverse Reactions (AASCARs) according to Race/Ethnicity and Purported Risk Factors

Variable	Allopurinol Initiators N (%)	Mortality Risk of Hospitalized AASCARs (/1000 persons)	Age-, Sex-Adjusted Relative Risk	Multivariable-Adjusted Relative Risk*
All	400,401 (100)	0.11 (0.08 to 0.14)	–	–
Race/Ethnicity
White/Hispanic	248,501 (62)	0.05 (0.03 to 0.09)	1.0	1.0
Black/Asian/Native Hawaiian/Pacific Islander	151,900 (38)	0.20 (0.14 to 0.28)	3.65 (1.90 to 6.99)	3.65 (1.90 to 6.99)
Sex
Male	213,041 (53)	0.07 (0.04 to 0.11)	1.0	1.0
Female	187,360 (47)	0.16 (0.11 to 0.22)	1.93 (1.01 to 3.70)	1.96 (1.02 to 3.74)
Age
<60 years	208,151 (52)	0.05 (0.03 to 0.09)	1.0	1.0
≥60 years	192,250 (48)	0.17 (0.12 to 0.23)	2.75 (1.37 to 5.53)	2.79 (1.39 to 5.59)
Chronic Kidney Disease
No	381,561 (95)	0.10 (0.07 to 0.14)	1.0	1.0
Yes	18,840 (5)	0.22 (0.07 to 0.52)	2.16 (0.77 to 6.04)	2.16 (0.77 to 6.09)
Initial Allopurinol Dose (>100 mg/d)
No	157,138 (39)	0.09 (0.05 to 0.15)	1.0	1.0
Yes	243,263 (61)	0.12 (0.08 to 0.17)	1.47 (0.77 to 2.78)	1.57 (0.83 to 2.98)

^*Mutually adjusted for the variables in this table.