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Activity Against ESKAPE Pathogens (MIC, μg/mL)a
| E. coli (AG212) | K. pneu (AG215) | A. baum (AG225) | E. cloacae (AG290) | P. aerug (AG220) | |
|---|---|---|---|---|---|
| Sisomicin 3 | 0.25–0.5 | 0.125 | 0.5 | 0.25–0.5 | 0.25–0.5 |
| 6′-(2-Hydroxyethyl)sisomicin 10 | 1 | 0.5 | 8–16 | 0.5–1 | 2–4 |
| 1-LHABA sisomicin 11 | 0.25–0.5 | 0.125 | 1 | 0.5 | 1 |
| Plazomicin 4 | 1 | 0.25–0.5 | 2–4 | 0.5–1 | 0.5–1 |
| Gentamicin 5 | 0.5–1 | 0.25 | 0.5–1 | 0.25 | 1 |
| Tobramycin 6 | 1 | 0.25–0.5 | 1 | 0.5 | 0.5 |
| Apramycin 18 | 4 | 1–2 | 4 | 2–4 | 4 |
All values were determined in duplicate using twofold dilution series.
