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. Author manuscript; available in PMC: 2019 Aug 3.
Published in final edited form as: J Mol Biol. 2018 Apr 7;430(16):2309–2320. doi: 10.1016/j.jmb.2018.04.003

Figure 3.

Figure 3

Structural basis of positive cooperativity for ligand binding by the KIX domain of CBP/p300. (A) The structures of the binary KIX:c-Myb complex (left, PDB ID: 1SB0) and the ternary MLL:KIX:c-Myb complex (right, PDB ID: 2AGH). For the binary complex, KIX is shown in gray and c-Myb is shown in orange. For the ternary complex, KIX is shown in blue, c-Myb is shown in purple, and MLL is shown in green. (B) Comparison of the structure of KIX in the binary (gray) and ternary (blue) complexes.