Table 1. n-Octanol-PBS Distribution Coefficients (log D7.4).
| radiometal | chelate chargea | 177Lu | 68Ga |
|---|---|---|---|
| c(avb6)-Trz-DOTPI | –4 | –4.13 ± 0.08 | no 68Ga labeling |
| c(avb6)-Trz-DOTAGA | –1 | –3.35 ± 0.03 | –3.32 ± 0.02 |
| c(avb6)-Trz-DOTA | 0 | –2.98 ± 0.08 | –3.10 ± 0.04 |
| c(avb6)-DOTAGA | –1 | –3.36 ± 0.07 | –3.49 ± 0.08 |
| c(avb6)-DOTA | 0 | –3.21 ± 0.24 | –3.37 ± 0.04 |
| c(avb6)-Ahx-NOPO | 0 | no 177Lu labeling | –3.06 ± 0.05 |
| c(avb6)-Trz-TRAP | |||
| (avebehexin) | –2 | no 177Lu labeling | –3.71 ± 0.03 |
a
Formal net charges for complexes with trivalent metal cations.