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Construction of PIPs to target the RBPJ-binding site in the promoter region of HES1. (A) Illustration of the reported14 binding site “(TG) TGGGAA” in the HES1 promoter region of RBPJ that is essential in governing the expression of the downstream gene HES1. (B) Chemical structures of the RBPJ-targeting PIPs termed PIP-RBPJ-1 and PIP-RBPJ-2.
