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Examples of the five core scaffolds of current Hsp90 inhibitors bound in the ATP-binding site of Hsp90. PDB designations of these structures are as follows: Ansamycins (GA) 4XDM; Natural Product Resorcinols NP (Radicicol) 4CE1; Synthetic Resorcinols (Ganetespib, Synta) 3TUH; Indanones (SNX-2112; Serenex) HSP902, 4NH7; Tropanones (XL888; Exelixis) 4AWO; Purines (PU-H71; Memorial Sloan-Kettering) 2FWZ
