Fig. 3.

NR4A1 promoted the mitochondrial dysfunction under high-fat damage. a, b The JC1 staining for the mitochondrial potential. c The opening rate of mPTP with NR4A1 knockdown or not. d, e The flow cytometry was used to analyze the mROS production. f The leakage of mitochondrial cyt-c into cytoplasm and nuclear via immunofluorescence assay. g–k Western blotting assay was carried out to analyze the changes of mitochondrial apoptotic proteins. *P < 0.05 vs. Ctrl group; #P < 0.05 vs. ox-LDL + si-Ctrl group