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. 2018 Jul 13;8:10656. doi: 10.1038/s41598-018-28874-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Profiling of miRNA expression after neonatal sevo treatment (P7-P7). (A) The P7-P7 group represents mice that were treated at P7 followed directly by tissue collection at P7. Profiling of the 599 known mouse miRNAs from the whole brain (B) and the hippocampus (C) yielded highly heterogeneous expression patterns. Neonatal sevo did not have a global effect on miRNA expression, comparing all miRNAs in the profiling data between the no sevo vs. sevo groups (Two-way ANOVA, (I) treatment: no sevo vs. sevo, P = 0.34 for the whole brain, P = 0.23 for the hippocampus; (II) miRNAs: comparing across miRNAs, P < 0.0001 for the whole brain and the hippocampus). (D and E) Volcano plots of the profiling data show both the fold change as a result of P7 sevo treatment and miRNAs that are differentially expressed with P < 0.05 (above the dotted line). Only miRNAs (red dots) with P < 0.05 and expression over 100 (relative unit defined by the Nanostring Technology) are selected to be in Table 1 for further analysis (Multiple t-tests).