Skip to main content
. 2018 Jul 13;7:130. doi: 10.1038/s41426-018-0132-z

Fig. 6. Serum from ZIKV infected animals collected after infection with DENV-2 demonstrate antibody dependent enhancement at a dilution of 1:100.

Fig. 6

Fold enhancement of DENV-2 infection in K562 cells using serum that was collected (a) from ZIKV-infected animals (n = 5) prior to DENV-2 infection and (b) at day 56 after DENV-2 infection. Statistical significance was determined using One-way ANOVA and differences between time-points were determined by post-hoc analysis using Tukey’s multiple comparisons test. A p < 0.05 was considered significant. (c) Percentage neutralization of DENV-2 using serum that was collected at day 56 post-infection from animals that was simultaneously infected with ZIKV and DENV-2 (n = 5). (d) Fold enhancement of DENV-2 infection in K562 cells using serum that was collected at 56 days from rhesus macaques that were simultaneously infected with ZIKV and DENV-2 (n = 5). Statistical significance was determined using One-way ANOVA and differences between time-points were determined by post-hoc analysis using Tukey's multiple comparisons test. A p < 0.05 was considered significant. Error bars represent standard error