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. 2018 Jul 13;8:10664. doi: 10.1038/s41598-018-28752-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alignment of structures of wild-type ALK and the non-active sites mutations. (a) Comparison of structures of wild-type ALK and C1156Y mutation. C1156Y results in marked conformational changes in activation segment (AS), αC helix and loop 1122–1130. (b) Comparison of activation segment structures of wild-type ALK (white) and different mutations (light magenta).