Table 3.
Performance of predictors of NASH and advanced fibrosis assessed by ROC curve analysis.
| SAF-Activity ≥2 | NAS ≥5 | Fibrosis >2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| miR-34a/197 | miR-192/197 | AST | miR-192/30c | miR-27b/30c | AST | miR-27b/197 | miR-27b/30c | FIB-4 | |
| AUC | 0.81 (0.72–0.90)* |
0.78 (0.69–0.88) |
0.75 (0.65–0.85) |
0.78 (0.69–0.88) |
0.79 (0.69–0.88) |
0.75 (0.64–0.85) |
0.75 (0.65–0.86) |
0.77 (0.67–0.87) |
0.85 (0.76–0.93) |
| Optimal cut-off | 4.43 | 2.55 | 33 | 1.62 | 2.83 | 33 | 2.28 | 2.34 | 1.68 |
| Sensitivity | 0.73 (0.58–0.85) |
0.74 (0.60–0.85) |
0.74 (0.59–0.85) |
0.87 (0.72–0.96) |
0.55 (0.38–0.71) |
0.79 (0.63–0.90) |
0.83 (0.64–0.94) |
0.72 (0.53–0.87) |
0.72 (0.53–0.87) |
| Specificity | 0.83 (0.67–0.93) |
0.79 (0.63–0.90) |
0.64 (0.48–0.78) |
0.69 (0.54–0.80) |
0.89 (0.77–0.96) |
0.59 (0.45–0.73) |
0.60 (0.47–0.72) |
0.74 (0.62–0.85) |
0.86 (0.75–0.93) |
| PPV (precision) | 0.83 (0.69–0.91) |
0.80 (0.66–0.90) |
0.71 (0.56–0.84) |
0.66 (0.52–0.86) |
0.78 (0.60–0.88) |
0.58 (0.43–0.76) |
0.49 (0.36–0.76) |
0.57 (0.42–0.77) |
0.70 (0.53–0.86) |
| NPV | 0.72 (0.57–0.87) |
0.72 (0.57–0.86) |
0.67 (0.52–0.81) |
0.88 (0.74–0.93) |
0.74 (0.59–0.89) |
0.80 (0.64–0.88) |
0.88 (0.74–0.93) |
0.86 (0.71–0.91) |
0.87 (0.74–0.94) |
| PLR | 4.17 (2.08–8.35) |
3.45 (1.89–6.31) |
2.07 (1.34–3.21) |
2.76 (1.83–4.17) |
4.97 (2.22–11.2) |
1.92 (1.35–2.78) |
2.09 (1.47–2.95) |
2.85 (1.77–4.60) |
5.07 (2.63–9.66) |
| NLR | 0.33 (0.20–0.53) |
0.33 (0.20–0.54) |
0.40 (0.24–0.68) |
0.19 (0.08–0.44) |
0.50 (0.35–0.73) |
0.35 (0.19–0.68) |
0.29 (0.13–0.65) |
0.37 (0.20–0.68) |
0.32 (0.18–0.59) |
| Accuracy | 0.77 (0.67–0.85) |
0.74 (0.64–0.83) |
0.70 (0.59–0.79) |
0.74 (0.64–0.82) |
0.73 (0.63–0.82) |
0.67 (0.57–0.77) |
0.66 (0.56–0.76) |
0.71 (0.61–0.81) |
0.82 (0.72–0.89) |
*Values within parenthesis indicate confidence intervals.
AUROC, area under the curve of the receiver operating characteristic; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood rate; NLR, negative likelihood ratio.