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. 2018 Jul 13;8:10600. doi: 10.1038/s41598-018-28855-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional maps of ORN activity. Ai-Aii. Example functional maps for seven unique odors in a representative Ano2^+/+ (top) and Ano2^−/− (bottom) animal. Molecular structures of the odors in the panel are depicted above. (B) Number of glomeruli per bulb (n = 11 Ano2^+/+ bulbs, n = 5 Ano2^−/− bulbs) responding to each of the seven odors above ROC threshold (threshold = 0.005 ΔF/F; p > 0.05, Wilcoxon rank-sum test with Bonferroni multiple comparison correction). (C) Example functional maps from four Ano2^+/+ and Ano2^−/− bulbs each for two different, but related odors. Glomeruli are represented as pseudocolored ellipses. The position of each ellipse reflects the location of a glomerulus within one olfactory bulb hemisphere. The black line designates the boundary of the imaged region of each olfactory bulb.