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. 2018 Jul 13;8:10600. doi: 10.1038/s41598-018-28855-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Odor responses in Ano2^−/− and Ano2^+/+ mice. (A) The 50 largest odor-evoked Ca²⁺ signals across all animals for each of the seven odors in both groups. Dashed lines and red bar indicate odor delivery period. Data are sorted by the largest mean response during odor delivery. (B) Traces of the 50 largest (top) Ca²⁺ responses for Ano2^+/+ and Ano2^−/− animals across all odors and 50 randomly selected responses (bottom). (C) Cumulative distribution of the mean Ca²⁺ response in the odor period across all glomerulus-odor pairs (n = 2093 Ano2^+/+ and 1526 Ano2^−/− glomerulus-odor pairs, p < 0.001 Kolmogorov–Smirnov test). (D) Cumulative distribution of the mean Ca²⁺ response across all odors at each glomerulus (n = 299 Ano2^+/+ glomeruli and 218 Ano2^−/− glomeruli, p < 0.001, Kolmogorov–Smirnov test). (E) The top 50 glomeruli ranked by mean response across all odors and further ranked by individual odor responses for Ano2^+/+ (right) and Ano2^−/− (left) animals. (F) Mean response of all glomeruli responding above ROC-defined threshold (threshold = 0.005 ΔF/F, Wilcoxon rank-sum test with Bonferroni correction, *p < 0.05, **p < 0.01, ***p < 0.001).