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. 2018 Jul 13;8:10600. doi: 10.1038/s41598-018-28855-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ORN responses in Ano2^−/− animals are enhanced at high odor concentrations. (A) Example multiphoton-acquired images of glomeruli and ΔF/F responses at three odor concentrations. Odor concentrations were normalized to the highest concentration (~10% v/v) using a photoionization detector (see Supplemental Fig. 4). (Bi-ii) Examples of the 25 largest responses to the highest concentration of Ethyl valerate followed through four other concentrations for Ano2^+/+ (top) and Ano2^-/- (bottom) animals. Individual traces are displayed below. Dashed line denotes odor onset and offset, red bar indicates odor period. (Ci-ii) Example traces from three glomeruli in part A, identified by arrowheads followed through four concentrations of Ethyl valerate (EV; top) and Allyl butyrate (AB; bottom) Di-ii. Mean response (filled circles) at eight odor concentrations for both odors and sigmoidal fit to each (Wilcoxon rank-sum, *p < 0.05, **p < 0.01, ***p < 0.001).