Table 4.

Independent determinants for LE in patients with Fabry disease with preserved LVEF

	Spearman’s r	P values	OR*	95% CI	P values	AUC	95% CI	P values
Clinical marker
NT-proBNP (pg/mL)†	0.47	<0.001	1.85	1.18 to 2.92	0.008	0.78	0.70 to 0.85	<0.001
Echocardiographic markers
IVSd (mm)	0.55	<0.001	1.65	1.25 to 2.18	<0.001	0.82	0.75 to 0.89	<0.001
LVMI (g/m²)	0.42	<0.001	1.03	1.01 to 1.05	0.002	0.75	0.66 to 0.83	<0.001
EF (%)	0.23	0.006	1.05	0.97 to 1.13	0.222	0.63	0.54 to 0.73	0.006
LAVI (mL)	0.39	<0.001	1.10	1.03 to 1.18	0.004	0.73	0.64 to 0.82	<0.001
Septal E/e′	0.60	<0.001	1.30	1.13 to 1.49	<0.001	0.86	0.79 to 0.92	<0.001
Lateral E/e′	0.54	<0.001	1.34	1.11 to 1.62	0.002	0.82	0.75 to 0.89	<0.001
Diastolic dysfunction grading	0.56	<0.001	2.98	1.61 to 5.526	0.001	0.78	0.70 to 0.86	<0.001
STI markers
Global LS_sys (%)	0.38	<0.001	1.16	1.00 to 1.34	0.047	0.73	0.65 to 0.81	<0.001
E/LSr_E (cm)	0.42	<0.001	1.03	1.00 to 1.05	0.015	0.74	0.65 to 0.82	<0.001
Mid-lateral LS_sys (%)	0.51	<0.001	1.20	1.07 to 1.34	0.002	0.83	0.75 to 0.90	<0.001
Mid-lateral LSr_E (s−1)	−0.44	<0.001	0.38	0.15 to 0.95	0.034	0.76	0.68 to 0.84	<0.001

*Adjusted for age, sex, BMI, NYHA functional class, GFR (DTPA).

†Ln transformed.

AUC, area under the curve; BMI, body mass index; E/e′, the ratio of early diastolic mitral inflow velocity to mitral annular tissue velocity; EF, ejection fraction; GFR (DTPA), glomerular filtration rate from 99mTc-diethylene triamine penta-acetic acid; IVSd, end-diastolic interventricular septal thickness; LAVI, left atrial volume indexed to body surface area; LE, late gadolinium enhancement; LS_sys, longitudinal systolic strain; LSr_E, longitudinal early diastolic strain rate; LVEF, left ventricular ejection fraction; LVMI, left ventricular mass indexed to body surface area; NT-proBNP, N-terminal pro-brain natriuretic peptide; NYHA, New York Heart Association; STI, speckle-tracking imaging.