Table 5.
Diagnostic performance of septal E/e′ for LE in patients with Fabry disease
| No LE (n=89) |
LE (n=57) |
Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | |
| Septal E/e′<7 (n=21) | 21 | 0 | 100 (92.1 to 100) | 23.6 (15.5 to 34.0) | 45.6 (36.7 to 54.7) | 100 (80.7 to 100) |
| Septal E/e′≥7 (n=125) | 68 | 57 | ||||
| Septal E/e′<10 (n=73) | 62 | 11 | 80.7 (67.7 to 89.5) | 69.7 (58.9 to 78.7) | 63.0 (50.9 to 73.8) | 84.9 (74.2 to 91.9) |
| Septal E/e′≥10 (n=73) | 27 | 46 | ||||
| Septal E/e′<14 (n=109) | 84 | 25 | 56.1 (42.4 to 69.0) | 94.4 (86.8 to 97.9) | 86.5 (70.4 to 94.9) | 77.1 (67.8 to 84.3) |
| Septal E/e′≥14 (n=37) | 5 | 32 | ||||
| Septal E/e′≤14.8 (n=116) | 87 | 29 | 49.1 (35.8 to 62.6) | 97.8 (91.3 to 99.6) | 93.3 (76.5 to 98.8) | 75.0 (65.9 to 82.4) |
| Septal E/e′>14.8 (n=30) | 2 | 28 |
E/e′, the ratio of early diastolic mitral inflow velocity to mitral annular tissue velocity; LE, late gadolinium enhancement; PPV, positive predictive value; NPV, negative predictive value.