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. 2018 Jul 9;4(2):e000678. doi: 10.1136/rmdopen-2018-000678

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© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an Open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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WOMAC (Western Ontario and McMaster Universities Arthritis Index) symptoms in the operated knee and contralateral knee over time and by treatment. The number of patients followed in the 800 IU group at each time point was baseline (BL)=136, 6 months=130, 12 months=130,18 months=123 and 24 months=115. The number of patients followed in the 2000 IU group at each time point was baseline=137, 6 months=129, 12 months=125, 18 months=118 and 24 months=111. Data points show least-square means based on repeated measurement analyses that included an indicator variable for treatment (800 IU vitamin D vs 2000 IU vitamin D), time, and the interaction between treatment and time, and were adjusted for the preoperative WOMAC function score (<52 vs ≥52) in the operated knee, presence of osteoarthritis in the non-operated knee, hospital site, and baseline age, gender, body mass index and Charlson Comorbidity Index (score 0–37). Symptoms in the operated knee (black) improved significantly over time for both function and pain, but not differentially by treatment. Symptoms in the contralateral knee (grey) stayed constant over time and did not change between treatment groups.