Table 2.
Brain regions with GMV negatively correlated to hallucination severity in participants with schizophrenia
| Number | Cluster size | Brain regions | Side | BA | MNI coordinate | Peak t value | ||
|---|---|---|---|---|---|---|---|---|
| x | y | z | ||||||
| 1 | 102297 | Superior frontal cortex | L | 6 | -24 | -7 | 72 | 4.17 |
| Superior frontal cortex | L | 9 | -14 | 45 | 50 | 4.90 | ||
| Precentral gyrus | L | 6 | -24 | -10 | 72 | 3.75 | ||
| Supplementary motor area | L | 6 | -4 | -12 | 52 | 2.57 | ||
| Middle frontal cortex | L | 10 | -37 | 61 | 5 | 4.77 | ||
| Middle frontal cortex | L | 46 | -34 | 50 | 32 | 3.62 | ||
| Precuneus | L | 30 | -4 | -54 | 10 | 2.71 | ||
| Precuneus | R | 30 | 8 | -52 | 8 | 2.75 | ||
| Anterior cingulum cortex | L | 32 | -3 | 44 | 13 | 3.11 | ||
| Anterior cingulum cortex | R | 32 | 12 | 38 | 10 | 4.02 | ||
| Middle cingulum cortex | L | 24 | -3 | 28 | 37 | 2.88 | ||
| Middle cingulum cortex | R | 24 | 6 | 27 | 34 | 2.97 | ||
| Calcarine cortex | L | 17 | -10 | -58 | 11 | 2.82 | ||
| Calcarine cortex | R | 17 | 4 | -57 | 11 | 2.55 | ||
| Hippocampus | L | 20 | -24 | -19 | -13 | 4.82 | ||
| Hippocampus | R | 20 | 24 | -18 | -16 | 3.17 | ||
| Parahippocampal gyrus | L | 30 | -18 | -32 | -12 | 4.26 | ||
| Thalamus | L | N.A | -5 | -20 | 17 | 3.15 | ||
| Thalamus | R | N.A | 7 | -18 | 20 | 3.06 | ||
| 2 | 24376 | Superior temporal cortex | R | 22 | 67 | -40 | 22 | 3.97 |
| Rolandic operculum | R | 48 | 47 | -4 | 6 | 3.35 | ||
| Insular cortex | R | 48 | 40 | -13 | 13 | 4.08 | ||
| 3 | 16800 | Middle frontal cortex | R | 10 | 38 | 59 | 8 | 3.26 |
| Middle frontal cortex | R | 46 | 41 | 39 | 30 | 3.02 | ||
| Middle orbitofrontal cortex | R | 11 | 18 | 67 | -11 | 4.04 | ||
| Inferior orbitofrontal cortex | R | 47 | 47 | 45 | -13 | 3.93 | ||
GMV gray matter volume, BA Broadmann area, MNI Montreal Neurological Institute, R right, L left
Automated Anatomical Labeling (AAL) software [94] and the Brodmann templates implemented in MRIcroN software (https://www.nitrc.org/plugins/mwiki/index.php/mricron:MainPage) were employed to define Brodmann area