Fig. 5.

Assessment of arthritic edema and arthritic score. Data is presented as the mean arthritic score ± SEM (n = 6/group). a Treatment mode of studies where the induction was done till day 13 and then dose was started. Edema in arthritic control group increased with the passage of time. IPR-EA and IPR-M have significantly decreased arthritic edema after 15th day in comparison to ibuprofen. b Preventive mode of study where dose was given after inducer at day 1. Arthritic control group has not prevented the induction of the disease while IPR-EA and IPR-M have significantly prevented arthritic edema in comparison to ibuprofen. c Arthritic score where arthritic control group has higher arthritic score compared to normal and other groups. The ibuprofen treated animals showed significant decrease in arthritic score after first week onwards during the experiment