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. 2018 Jul 13;19:536. doi: 10.1186/s12864-018-4903-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Selected events of tumor-specific APA regulations that do not fit the 3’ UTR length modulation paradigm. (a,b) CDKN2A in KIRC and HNSC. (c) EZH2 in LUAD. (d) PTCH1 in BRCA. (a-d) The legend of Fig. 2 applies. In addition, when the 3’ UTR length change is too complex to be resolved into a shortening or lengthening trend, the corresponding text box is left uncolored. NMD-related transcript elements are colored in cyan. An orange arrow indicates that a predicted CS with a significant frequency change is mapped to multiple stop codons, with its associated 3’ UTR length being ambiguous. A high-resolution version of this figure is available for download in Additional file 5